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Image of What is GABA and why is it so important?
Vitamins & Supplements

What is GABA and why is it so important?

Image of Caya Kerkhof

GABA. A small name with a big impact. You may have come across the term before in books, blogs or podcasts about neurotransmitters. But what exactly is GABA? We’ll walk you through it.


What is GABA and how does this neurotransmitter work in your brain?

GABA stands for gamma-aminobutyric acid. It is a neurotransmitter—a chemical messenger that helps nerve cells communicate with one another. While some neurotransmitters activate the brain, the neurotransmitter GABA does the opposite: it dampens overactivity.

Your body produces GABA itself—from glutamate, a substance with a more stimulating effect. This happens with the help of the enzyme glutamate decarboxylase (GAD) and vitamin B6. Without enough B6, this conversion becomes more difficult. All the more reason to make sure your diet is up to scratch!

GABA in foods: natural sources of this neurotransmitter

Although your body makes GABA itself, you can also take it in through your diet. Think of fermented products such as kimchi, miso and tempeh. Wholegrain rice, spinach, tomatoes and sweet potatoes also naturally contain small amounts of GABA.

There are also nutrients that support GABA production. L-theanine, for example—an amino acid found in green tea. And, as mentioned earlier, vitamin B6. Plenty of reasons, then, to eat a healthy, varied diet!

The relationship between GABA and alcohol: what you should know

Alcohol temporarily enhances the effect of GABA—which explains the relaxed feeling after a drink. However, this effect is short-lived. In the long term, alcohol can actually disrupt your natural GABA balance. So if you want to support your GABA activity, it’s better to focus on the right diet and sufficient relaxation.

Good to know

GABA is a neurotransmitter. Your body produces it itself, but diet and lifestyle choices can support this process.

Sources

  1. Enna, S. J., & McCarson, K. E. (2006). The role of GABA in the mediation and perception of pain. Advances in Pharmacology, 54, 1-27.
  2. Jung, M. E., et al. (2007). Effects of oral administration of GABA on neurotransmitter levels in the brain. Journal of Nutritional Science and Vitaminology, 53(4), 348-351.
  3. Lader, M. (2011). Benzodiazepines revisited—will we ever learn? Addiction, 106(12), 2086-2109.
  4. Lancel, M. (1999). Role of GABA(A) receptors in the regulation of sleep. European Journal of Pharmacology, 375(1-3), 1-13.
  5. Nemeroff, C. B. (2003). The role of GABA in the pathophysiology and treatment of anxiety disorders. Psychopharmacology Bulletin, 37(4), 133-146.
  6. Petty, F. (1995). GABA and mood disorders: a brief review and hypothesis. Journal of Affective Disorders, 34(4), 275-281.
  7. Weiner, J. L., & Valenzuela, C. F. (2006). Ethanol modulation of GABAergic transmission: the view from the slice. Pharmacology & Therapeutics, 111(3), 533-554.
  8. Winkelman, J. W., et al. (2008). Reduced brain GABA in primary insomnia: preliminary data from 1H-MRS. Sleep, 31(11), 1499-1506.